Pathological effects of ECHINOSTOMA PARAENSEI infection associated with pyogenic abscesses caused by PSEUDOMONAS AERUGINOSA in swiss mice

Autores

  • Juberlan Silva Garcia Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia e Parasitologia de Mamíferos Silvestres, Rio de Janeiro, Rio de Janeiro, Brazil, garciajsg@gmail.com https://orcid.org/0000-0002-8841-2557
  • Raquel de Oliveira Simões Universidade Federal Rural do Rio de Janeiro (UFRRJ), Departamento de Parasitologia Animal, Seropédica, Rio de Janeiro, Rio de Janeiro, Brazil, raquel83vet@gmail.com https://orcid.org/0000-0001-5130-3341
  • Ester Mota Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Patologia, Rio de Janeiro, Rio de Janeiro, Brazil, mota.ester@gmail.com https://orcid.org/0000-0003-0712-3874
  • Incerlande Soares dos Santos Fundação Oswaldo Cruz, Instituto de Ciência e Tecnologia em Biomodelos, Serviço de Controle da Qualidade Animal, Rio de Janeiro, Brazil, incerlande@fiocruz.br https://orcid.org/0000-0002-3588-1122
  • Arnaldo Maldonado Júnior Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia e Parasitologia de Mamíferos Silvestres, Rio de Janeiro, Rio de Janeiro, Brazil, arnaldomaldonadojunior@gmail.com https://orcid.org/0000-0003-4067-8660

DOI:

https://doi.org/10.5216/rpt.v50i1.66670

Resumo

The trematode Echinostoma paraensei is an intestinal parasite transmitted by ingestion of the infectious stage of metacercariae. For scientific purposes, its life cycle has been maintained in the laboratory, allowing analysis using various biological approaches. Different parasite isolates have revealed atypical patterns of migration and establishment in ectopic sites in Swiss-Webster mice. During the investigation of the biological life cycle of an E. paraensei isolate from the silvatic rodent Nectomys squamipes collected in the municipality of Rio Bonito (State of Rio de Janeiro), a bacterial coinfection with Pseudomonas aeruginosa was observed, which produced anatomopathological alterations, mainly in the liver, bile ducts, pancreas, and small intestine. The main macroscopic signs were the whitish suppurative pyogenic punctual lesions. The histological sections stained by hematoxylin-eosin showed an intense inflammatory reaction formed by mononuclear cells and macrophages surrounding the bile ducts, although the hepatic parenchyma still presented its normal aspect. Thus, pyogenic abscesses can be associated with E. paraensei infection depending on the strain and aggravating pathogenesis in the definitive host.
KEY WORDS: Liver abscess; Swiss mice; trematode infection.

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Publicado

22-02-2021

Como Citar

Silva Garcia, J., Simões, R. de O., Mota, E., Soares dos Santos, I., & Maldonado Júnior, A. (2021). Pathological effects of ECHINOSTOMA PARAENSEI infection associated with pyogenic abscesses caused by PSEUDOMONAS AERUGINOSA in swiss mice. Revista De Patologia Tropical / Journal of Tropical Pathology, 50(1), 40–48. https://doi.org/10.5216/rpt.v50i1.66670

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ARTIGOS ORIGINAIS / ORIGINAL ARTICLES