Hyptis brevipes AND Paullinia pinnata EXTRACTS AND THEIR FRACTIONS PRESENTING ACTIVITY AGAINST Mycobacterium abscessus subsp. massiliense

Autores

  • Rogério Coutinho das Neves Instituto de Patologia Tropical e Saúde Publica
  • Rayanny Gomes Andrade Laboratory of Molecular Bacteriology, IPTSP, DEBIOTEC, UFG, Goiânia, Brazil.
  • Carlos Alexandre Carollo Laboratory of Natural Products and Mass Spectrometry, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • Amanda Galdi Boaretto Laboratory of Natural Products and Mass Spectrometry, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • Andre Kipnis Laboratory of Molecular Bacteriology, IPTSP, DEBIOTEC, UFG, Goiânia, Brazil.
  • Ana Paula Junqueira- Kipnis Laboratory of Immunopathology of Infectious Disease, Tropical Institute of Pathology and Public Health (IPTSP), Department of Biosciences and Technologies (DEBIOTEC), Federal University of Goiás (UFG), Goiânia, Brazil.

DOI:

https://doi.org/10.5216/rpt.v48i3.58993

Resumo

Medicinal plants are of great interest for the discovery of new biomolecules with diversified effects. Over the last decade different outbreaks caused by Mycobacterium abscessus subsp. massiliense have been reported, evidencing it as an important emerging pathogen in underdeveloped countries. This study investigated the antimycobacterial activity of six Brazilian medicinal plant extracts and their fractions. Hyptis brevipes, Tocoyena formosa, Randia armata, Paullinia pinnata, Lafoensia pacari and Anadenanthera colubrina were evaluated against M. a. massiliense. Total extracts from the medicinal plants H. brevipes, T. formosa, P. pinnata and L. pacari presented a minimal bactericidal concentration of 1 mg/mL. After fractioning, the ethanolic fractions from H. brevipes and P. pinnata presented bactericidal activity, and the ethyl acetate fraction from H. brevipes and T. formosa presented antimycobacterial action. The best bactericidal function of all plant fractions was the ethanolic, which contained rutin and rosmarinic acid that were shown to have microbicidal activity.

KEY WORDS: Mycobacterium abscessus; medicinal plants; Brazilian medicinal plants; HPLC
and biodiversity.

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Publicado

07-11-2019

Como Citar

das Neves, R. C., Gomes Andrade, R., Alexandre Carollo, C., Galdi Boaretto, A., Kipnis, A., & Paula Junqueira- Kipnis, A. (2019). Hyptis brevipes AND Paullinia pinnata EXTRACTS AND THEIR FRACTIONS PRESENTING ACTIVITY AGAINST Mycobacterium abscessus subsp. massiliense. Revista De Patologia Tropical / Journal of Tropical Pathology, 48(3), 148–160. https://doi.org/10.5216/rpt.v48i3.58993

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Seção

ARTIGOS ORIGINAIS / ORIGINAL ARTICLES